Chapter 1. What are sarms?
You probably have a friend at the gym or who does CrossFit who has mentioned they use SARMS, but neither of you really knew much about them besides they helped him/her get over a plateau. SARM stands for selective androgen receptor modulator. There is some slight confusion by people new to this topic who confuse SARM with SERM. SERM’s (selective ESTROGEN receptor modulators) are drugs that block estrogen from looping back into the pituitary glands and are not considered performance enhancers at all.
SARMS, on the other hand, ARE performance enhancers. They are being developed or were developed, for the main purpose of binding to cellular androgen receptors. The purpose was to give the same beneficial effects as anabolic steroids, but in a selective manner, which means way fewer bad effects for men and especially women who use them. Read more on this here.
There are several SARMS out there which will be discussed below, each having different attributes. Overall the medical community developed them to fight obesity, fight disease, fight muscle wasting, and help with bone health. Athletes have recognized their amazing properties, and in the fitness community they are now used to help build lean muscle mass, burn fat, and boost athletic performance.
Chapter 2. History
SARMS have been developed since post-WWII by modifying the testosterone molecule. Big pharma has been increasing their testing over the past couple decades with the goal of having one approved that would replace testosterone replacement therapy, drugs/hormones for muscle wasting, and osteoporosis issues.
The problem with using anabolic steroids for muscle wasting or hormonal replacement is the side effects. SARMS do not come with the prostate problems, acne, hormonal roller coasters, and virilization in females (which causes man-like features like deepening voice and body/facial hair)
As of 2018, there are currently at least 5 SARMS which have been abandoned, at least a half dozen in pre-clinical trials, and a few in the clinical testing phase.
Chapter 3. Types of sarms?
GW-501516 (cardarine) and SR9009 (stenabolic) are NOT SARMS. GW is a PPAR receptor agonist, and SR is a Rev-ErbA agonist. However, both are still sold as SARMS are referred to as SARMS in the industry. They both are excellent at fat burning and especially boosting endurance. GW dosage should be 10-20mg per day, while SR9009 dosage is 5-20mgs pre-exercise.
MK-677 (Ibutamoren or Nutrobal) is also NOT a SARM but popularly sold as one. It is actually a growth hormone secretagogue. Instead of suppressing your growth hormone, it actually will add to it. People who use it will notice a boost in performance, rapid increase in hunger, and even fat loss. The dosage recommended is 12.5mg 1-2X per day.
LGD-4033 (anabolicum) is an actual SARM and maybe the most consistent in terms of its use during a calorie deficit to prevent muscle wasting. Users also say they experience a boost in lean muscle mass, some strength, and fat loss. The recommended dosage is 5-10mgs a day.
MK-2866 (Ostarine) is also a SARM and is popularly used on cycle and also can be used in PCT or bridge at proper dosages. When used at 25mgs a day or less, for 4 weeks or less, it is not suppressive. It is excellent at producing lean muscle mass, fat loss, and also at helping with soft tissue health.
S4 (andarine) is a SARM which is known for its ability to increase strength better than even LGD. It also can be used for lean muscle mass and fat loss as well. Users typically run 25-75mgs per day.
RAD140 (Testolone) is the most powerful SARM that is popularly available. Users are recommended to use 10mg a day. Expect a boost in lean muscle mass, libido, and strength when using it.
Chapter 4. Side effects
Since GW501516, SR9009, and MK-677 are not SARMS, they are nonsuppressive.
The side effects of GW and SR are minimal when used at proper dosages.
The biggest complaint with MK-677 is the hunger issue, also if abused you can develop similar side effects as you would get on human growth hormone-like internal growths, some bloating, and carpal tunnel.
LGD side effects are suppression. It is considered the most suppressive of the main SARMS that are popularly sold, so it is important to run a PCT after using.
MK-2866 is suppressive when used at more than 25mgs a day, for more than 4 weeks, therefore a PCT is needed in that situation.
S4 binds to receptors around the eyes which can cause vision issues, especially at higher dosages. I do not recommend driving at night while on S4 for this reason. It also is suppressive where a PCT is needed.
RAD140 is extremely strong and suppressive, almost as suppressive as anabolic steroids. You should always run a PCT after using it.
*Note even though the SARMs above are suppressive, they are still not as suppressive as anabolic steroids which will send LH levels crashing to 0.
Chapter 5. Where to buy SARMs
Legally SARMS are sold for research only, and many US financial processors have cracked down on their sales over the past year or two. This has caused a cascading effect which has driven companies who produce the products underground and have made SARMS more difficult to find. Add to this the problem of a lot of fake products coming from China, and you have a very difficult situation for consumers.
One of the true dangers is many companies have been caught spiking their products with pro hormones which is extremely dangerous. If the user is female she will notice severe side effects such as enlarged clitoris and other virilization issues discussed above. If the user is a male he may notice gyno (bitch tits), other estrogen problems, and even liver toxicity.
You must be smart as a buyer of SARMS and only trust approved sources.
Chapter 6. Stacking
SARMS are extremely versatile and can be used solo or as part of a stack.
Section 1. With anabolic steroids:
I recommend stacking GW501516 with trenbolone as it will help offset endurance problems. You can also use GW in any steroid stack to increase endurance and fat loss. LGD is popularly used with steroids to add to gains without adding to side effects, and finally, Ostarine is used to help keep the soft tissues healthy.
Section 2. PCT:
Post Cycle therapy is extremely important at ensuring a soft landing coming off anabolics. GW501516, SR9009, and Nutrobal are nonsuppressive so they can be utilized during PCT. A lot of guys have also used Ostarine at proper dosages as it will help prevent muscle wasting.
Section 3. Bulking:
If you choose to bulk nothing is better than Nutrobal at increasing hunger. LGD also makes a great option when it comes to boosting lean muscle mass.
Chapter 7. Cutting:
Using either GW or SR is very important during a cut because they are so good at fat loss. The most popular cutting stack is GW + S4, combined with eating in a deficit. You will shred on that stack.
Section 1. Supplement stack:
Creatine can be stacked with any SARM as a natural to boost recovery and gains. I also recommend Hcgenerate as a testosterone booster and you can stack it with LGD and S4.
Section 2. Triple stack:
I saved the best for last. The triple stack is the most popular SARMS stack of all time. It combines GW, S4, and Ostarine together. You will experience amazing lean muscle gains, fat loss, and a boost in endurance where you will be an animal in the gym.