LGD-4033 (Anabolicum)

LGD 4033 or Anabolicum is a ‘Selective Androgen Receptor Modulator’ (SARM) that has been developed to work its anabolic magic on the muscle tissue. It is one of the newer types of SARMs; it does produce similar results to steroids but without the horrible side effects. Realistically, it is the most potent SARM on the market and this is good news if you want to get some serious gains. Let’s move on and see what LGD-4033 is really all about…

Chapter 1. The benefits of using LGD-4033

• LGD boosts your strength levels.
• Improves your lean muscle mass.
• It does have bone and muscle healing properties.

Chapter 2. How LGD-4033 works

LGD-4033 works by binding to selective androgenic receptors in both the muscle and bone tissues. Therefore, this potent SARM bypasses the tissues of the major organs such the heart, prostate, colon and sebaceous glands.  This process eliminates the harmful side effects that are caused by steroids, because they don’t have any affinity with the tissues in these major organs.

Section 1. Protects muscle mass

LGD-4033 can be consumed to prevent muscle wastage, and it does have certain bone healing/strengthening properties. This relates to the way that LGD-4033 targets and then ultimately binds to the muscle and bone cells. Not only is LGD-4033 good for bodybuilders to preserve muscle but it can be used for age-related muscle loss.  Muscle loss in men does start to decline at around 35 years. Therefore, a good strategy in slowing down this process is to add in some LGD-4033 into your supplementing regime.

Chapter 3. The Impact of LGD-4033

The effects of LGD-4033 can range from bulking to cutting body transformations. For bulking bodybuilders can expect to gain strength and muscle mass, when combined with the correct amount of calories and macronutrients. If you use LGD-4033 during this phase, you will not look bloated and you will not suffer from water retention. This means that the total weight gained will be from muscle mass and not water retained in the body.

Section 1. The cutting phase

During the cutting phase, it is extremely important to protect your lean muscle mass- at all costs! When stripping fat, a strategy is to consume less calories less than you expend. Unfortunately, without the proper protection this can lead to muscle wastage, as the body begins to break down the muscle tissue. Subsequently your body use your hard-earned muscle mass as a fuel source. This is a nightmare scenario for any serious lifter but it can be avoided…

To stop this nightmare from occurring or reoccurring, invest in some LGD 4033 as this SARM will definitely protect your muscle tissue from being cannibalized. Think of LGD-4033 as an inner bodyguard protecting the breakdown of the muscle mass. Due to its unique ability to bind to the muscle tissue (we have already established this), it does produce a cleaner, harder and more muscular body during this phase.

A top tip in protecting your muscle mass is to combine a high protein diet with LGD 4033, as this keeps your metabolism high. This scenario facilitates a constant fat burning environment especially when mixed in with a HIIT (high intensity interval training) training regime.

Section 2. The bulking phase

There is some anecdotal evident to suggest that LGD-4033 ‘directly’ strips unwanted fat. To be honest the jury is out on this! However, LGD-4033 does increase your lifting endurance and this may be the catalyst for the increase in fat burning throughout the body. A key point to consider is that there is a strong connection between lifting duration, burning fat and building muscle mass. Natural testosterone does tend to dip around the 45 minute mark when lifting (1) and this tipping point should be noted if you want to achieve either gains and/or fat loss.

1) The bulking research

LGD-4033 is also called Ligandol and Anabolicum; it is one of the better researched SARMs.  It has been examined through numerous studies and it has produced some very interesting results. Healthy subjects who consumed 15 mg of LGD-4033 for 21 days had a significant increase in muscle growth (2). In another study the cohort took LGD-4033 dosages of 22 mgs, they had an increase in muscle mass and no side effects (3).

(A) Mean ( SE ) lean mass (kg) change from baseline up to day 28. Change from baseline in lean body mass is shown.

Chapter 4. Side effects

The current research indicates that there are no side effects associated with LGD-4033. The main reason is because this SARM does not have an estrogenic nature. Thus, there are no reported health issues such as: water retention, bloating, gynecomastia, acne, hair loss, prostate issues, liver toxicity, cardiovascular or high blood pressure associated with LGD 4033.

Nevertheless, LGD-4033 may suppress the production of testosterone but this scenario is very much temporary. There is a slight suppression in natural testosterone levels, but this really depends if you exceed the recommended dosages. However, your natural testosterone levels should never dropped outside of the normal range when supplementing with LGD-4033. In addition, normal testosterone levels are reinstated within the body at around the 3 week mark when you stop taking this potent SARM (2).

Chapter 5. Dosage

LGD 4033 has a half-life of around 30 hours. For the best results you should consume it orally once a day, with a dose range between 10-22 mg. It can be stacked with other SARMs such as MK-2866 and GW-50156 (feel free to read the articles on both of these SARMs). Use for a four week cycle and then have a 4 week break off it. This gives your natural testosterone levels time to recover properly.

Chapter 6. Summary

LGD-4033 can enhance your lean muscle mass, lifting strength and endurance. It has no recorded side effects and can be used in both the cutting and bulking phase of your training program. Take between 10-22mg once per day for the best results, and you can stack it with other SARMs (MK-2866 and GW-50156) to further boost your gains.

Chapter 7. References

1. Basaria S, Collins L, Dillon EL, Orwoll K, Storer TW, et al. (Jan 2013). “The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men.”. J Gerontol A Biol Sci Med Sci. 68: 87–95. PMC 4111291  . PMID 22459616. doi:10.1093/gerona/gls078.

2. Jump up to:a b Basaria, S., L. Collins, E. L. Dillon, K. Orwoll, T. W. Storer, R. Miciek, J. Ulloor, A. Zhang, R. Eder, H. Zientek, G. Gordon, S. Kazmi, M. Sheffield-Moore, and S. Bhasin. “The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 68.1 (2012): 87-95. Web. 21 Nov. 2016.

3. Jump up^ “Ligand Presents New Preclinical Data on its Lead SARM Molecule LGD-4033 at the Gerontological Society of America Annual Meeting” (Press release). San Diego: Ligand Pharmaceuticals. November 20, 2009. Retrieved November 23, 2014.